| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Top Grade Pure Rapamycin Sirolimus Powder Sirolimus 99% CAS 53123-88-9
Rapamycin is a macrolide compound obtained from streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production.
Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.
Function
It is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2).
Application
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.
Comany Information
HOTA wants to help its clients to feel that they have control over their own health. That is why, as a passionate company, we have supplied professional food supplements and plant extracts.
As yet, many people remain unaware that so much can be achieved through food, exercise and supplementation. And that is a missed opportunity, both for the individual and for society. That is why we ensure that our expert knowledge is widely accessible. We actively look for increased knowledge and we substantiate everything that we say, do and produce with scientific research.
We see a future with a better quality of life for everyone: Living Quality. Everything that we strive for has just one single goal: to give you better control of health.
HOTA is dedicated to ensuring every one of our customers enjoys the best in service and product quality. If you have any questions or concerns, our team is always available to help you out!
More Advantages:
1. Leading factory price
2. Huge range of product in stock
3. Research & Development
Our R&D team is continuously developing new product to meet the market.
4. Quality control
At HOTA Co., Ltd, this process is probably the most stringent of all. To us, quality is a commitment. It is a constant process and a continuous improvement.
5. OEM Service: Capsules or Tablets available
Safe, Secure Packaging - Full sealed
1-25kgs: Aluminium bag outside and double plastic bags inside
More than 25kgs: Fiber drum outside and plastic bags inside
Fast, Secure Shipping
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By Express |
By air |
By sea |
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Suitable for under 25kg |
Suitable for more than 25kg |
Suitable for more than 500kg |
Q1: When will my order be shipped?
A: Within 3 working days after the payment.
Q2: Can i get some samples?
A: Yes, contact me to know more about sample
Q3: How to confirm the Product Quality before placing orders?
A: Every product is with professional COA. Please be sure about the quality.
If any doubt, sample is available to you to be tested before large quantity order.
Q4: How to start orders or make payments?
A: Payment by T/T, Western Union,MoneyGram etc .
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